AB0643 THE ANALYSIS OF RISK FACTORS FOR PRETERM BIRTH AND LOW BIRTH WEIGHT IN SLE PATIENTS WITH OR WITHOUT ATTAINED LLDAS AT THE CONCEPTION

Background Women with systemic lupus erythematosus (SLE) have a higher risk for adverse pregnancy outcomes (APOs) including preterm birth (PB) and low weight (LBW) [1]. These APOs are revealed to be related uncontrolled disease activity during [2]. Currently, state (LLDAS), which is comprehensive index, suggested the treatment target control damage accumulation. However, it controversial whether achieving LLDAS can sufficient therapeutic prevent APOs. Objectives We analyze factors PB LBW in SLE patients or without at conception. Methods used data of who been treated planning from single center cohort. divided into achieved group non-achieved group, evaluated rate outcomes, especially weight. also analyzed agents (glucocorticoid use their doses), serum immunological parameters (C3, C4, CH50 levels titer anti-dsDNA antibody). Results In 66 pregnancies complicated SLE, 42 cases (63.6%) conception, while other 24 (36.4%) did not. Table 1 showed by separately attained not-achieved group. As PB, mean glucocorticoid dose became factor both not-attained (P=0.02 0.01). addition, only that not achieve LLDAS, C3 were associated PB. On hand, use, dose, identified as addition (P=0.04, <0.01, 0.02, 0.045). None these achievement. 1. Risk achievement Achieved Not (+) (n=5) (-) (n=33) P value (n=7) (n=12) Glucocorticoid ## 4 (80.0) 25 (75.8) 1.00 7 (100.0) 11 (91.7) Mean mg/day 7.8±2.1 4.8±1.7 0.02* 14.9±4.2 10.5±2.0 0.01* C3, md/dl # 86.6±18.0 95.0±21.9 0.53 70.7±17.9 96.8±18.8 <0.01* mg/dl 20.0±5.5 19.6±6.5 0.88 12.8±10.4 19.3±5.6 0.06 CH50, IU/l 40.9±9.4 41.8±9.2 0.78 34.2±11.3 43.1±8.4 0.09 Anti-dsDNA antibody, 15.1±26.0 1.8±4.5 0.07 44.9±87.9 13.5±16.2 0.46 (n=26) 12 17 (65.4) 0.04* 6.7±1.6 4.1±1.5 13.8±4.4 11.2±2.9 0.17 83.6±15.6 99.4±22.3 0.045* 75.1±17.5 94.0±22.4 18.8±3.9 20.2±7.3 0.99 15.2±9.6 18.0±7.3 0.29 36.3±4.6 44.4±9.7 36.8±10.5 41.1±10.3 0.36 6.9±17.4 2.1±5.0 0.54 44.4±88.1 13.8±16.2 0.58 (Values presented ± standard deviation number (%). Wilcoxon rank sum test; Fisher’s exact *P < 0.05.) Conclusion was found regardless LBW, shown even if could Therefore, important strictly improving References [1]Bundhun PK, Soogund MZ, Huang F. Impact on maternal fetal following pregnancy: meta-analysis studies published between years 2001–2016. J Autoimmun. 2017;79:17-27. [2]Clowse ME, Magder LS, Petri M. The clinical utility measuring complement antibodies erythematosus. Rheumatol. 2011;38:1012-6. Acknowledgements: NIL. Disclosure Interests Declared.